More On Prolactin Benefits!

The drug Risperdal/Risperidone is an immune modulator as it enhances the hormone prolactin.
So, this is working in a way similar to Low Dose Naltrexone, although through a different hormone.

Prolactin - "contribute to maturation as well as functioning of the immune cells"  "maintaining balance within immune reactions". 

When I was highly inflamed, before I took Low Dose Naltrexone, my prolactin level was low normal for post-menopausal women.  My eyes were very dry.  The Risperdal at a low dose helped with the dry eyes, possibly modulating my immune response.

"Prolactin/PL gene polymorphisms have now been shown to be linked to RA (Rheumatoid Arthritis). Thus, manipulation of PL may have significant clinical utility."   (Annals of NY Academy of Sciences, 1999)

"Since hyperprolactinemia and hypoprolactinemia are both immunosuppressive, physiological levels of circulating PRL must be necessary to maintain normal immunocompetence. Moderate increases in PRL during immune stimulation of the hypothalamic-pituitary axis may counteract glucocorticoid inhibition, whereas inappropriate prolongation of PRL synthesis could lead to autoimmune diseases. Increased release of PRL by the pituitary during stress may inhibit NK cell antitumor cytotoxicity. The variety of PRL isotypes, the existence of multiple receptor subunits, and the complexity of their intracellular signaling may explain the specificity of PRL action on different target cells."  (Neuroimmunmodulation, 1997)

Other studies show that too much prolactin, or "oversupply",  is also not good.  Oversupply maps to disease activity for SLE, celiac and possibly others.

Our family dosage is very small (.5 mg Risperdal or less), and the testing shows my prolactin to be at just above "post menopausal normal range".   I get tearing in my eyes when my risperdal (prolactin) dose is too high, so that serves me well in understanding how much to take.

Below you will find a 2010 abstract that describes the effects of prolactin and possible impacts on autoimmune disease.